ZIA CP010131-04123 (ZIA) | |||
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Title | Cancer risk in peptic ulcer patients | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Kleinerman, Ruth | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $3,516 | Project Dates | 01/01/1984 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Diabetes (15.0%) |
Lung (25.0%) Pancreas (25.0%) Stomach (25.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Mortality in a cohort of 4000 peptic ulcer patients, half of whom received external beam radiation, was compared to the U.S. population. Risks for organ specific cancers were compared between irradiated and nonirradiated peptic ulcer patients, and dose-response relations were evaluated. Co-factors such as age, gender, tobacco smoking habits, and gastric surgery were considered in the analysis. Increased risks for cancers of the stomach, pancreas and lung were related to radiation exposure as well as coronary heart disease. |